ELSO COVID-19 Resources
ELSO is providing this website as a resource for centers who may be called on to
manage COVID-19 patients. As this is an emerging infectious disease, the scientific
data is constantly evolving. The contents of this page will change rapidly as new
information develops. For real time updates, please follow ELSO’s social media
accounts at Twitter (@ELSOOrg and @ECMOed) and Facebook (https://www.facebook.com/ELSO.Org) as well as the ECMOed
COVID-19 page (https://elso.blog/category/2019ncov-2/)
COVID-19 Cases on ECMO in the ELSO
Registry:
|
Total COVID-19
Cases |
COVID-19
Confirmed Cases
9860 |
|
Total counts of COVID-19 confirmed patients.
|
|
Patients who initiated
ECMO at
least 90 days ago |
COVID-19
Confirmed
8036 |
COVID-19
In-hospital
Mortality
48%
|
| COVID-19 ECMO counts by ELSO Chapter |
| North
America |
6422
|
| Europe |
2053
|
|
Asia Pacific |
144
|
|
Latin America
|
650
|
|
SWAAC |
627
|
|
Reports counts of ECMO-supported suspected or confirmed COVID-19
cases by ELSO Chapter (provided the chapter has at least 5 cases
reported)
|
|
FULL COVID-19
REGISTRY DASHBOARD
|
|
Disclaimer
|
Reporting COVID-19 Cases into the ELSO Registry
Confirmed COVID-19 cases should utilize the ICD-10 emergency code U07.1,
2019-nCoV acute respiratory disease as the primary diagnosis. In an effort to
better understand the impact of COVID-19 on ECMO we have also added a question
asking if a patient has COVID-19.
There are 4 response options:
Guidelines for ECMO in COVID-19
Updated 2021 Guidelines from the Extracorporeal Life Support Organization (ELSO).
COVID-19 Critical Care Consortium
ExtraCorporeal Membrane Oxygenation for 2019 novel
Coronavirus Acute Respiratory Disease (COVID-19
Critical Care
Consortium) is a prospective/retrospective
multi-center short period incidence observational study
of intensive care
unit patients with COVID-19.
COVID-19 Critical Care Consortium
Euro-ELSO
EuroELSO has established a COVID-19 survey and has released results. This is an ongoing effort in the region and we will continue to update this section as more results become available.
Euro-ELSO Survey
Select Scientific
Literature regarding ECMO Use for COVID-19:
ELSO Lancet COVID-19 Article
ANN ARBOR, MI - Sept. 25, 2020 -
The Extracorporeal Life Support Organization (ELSO) announced today
publication in The Lancet of registry findings examining the
treatment of COVID-19 patients with extracorporeal membrane oxygenation
(ECMO) support. The results show that for ECMO-supported patients with
COVID-19, estimated in-hospital mortality 90 days after ECMO and
mortality rates in those with a final disposition of death or discharge
were under 40 percent.
Full Press Release
The Lancet Article
- Original Research
- Extracorporeal membrane
oxygenation support in COVID-19: an international cohort study
of the Extracorporeal Life Support Organization registry.
Barbaro RP, MacLaren G, Boonstra PS, Iwashyna TJ, Slutsky AS, Fan E,
Bartlett RH, Tonna JE, Hyslop R, Fanning JJ, Rycus PT, Hyer SJ,
Anders MM, Agerstrand CL, Hryniewicz K, Diaz R, Lorusso R, Combes A,
Brodie D; Extracorporeal Life Support Organization. Lancet. 2020 Oct
10;396(10257):1071-1078. doi: 10.1016/S0140-6736(20)32008-0. Epub
2020 Sep 25.PMID: 32987008
- Extracorporeal membrane
oxygenation for severe acute respiratory distress syndrome
associated with COVID-19: a retrospective cohort study.
Schmidt M, Hajage D, Lebreton G, Monsel A, Voiriot G, Levy D, Baron
E, Beurton A, Chommeloux J, Meng P, Nemlaghi S, Bay P, Leprince P,
Demoule A, Guidet B, Constantin JM, Fartoukh M, Dres M, Combes A;
Groupe de Recherche Clinique en REanimation et Soins intensifs du
Patient en Insuffisance Respiratoire aiguE (GRC-RESPIRE) Sorbonne
Université; Paris-Sorbonne ECMO-COVID investigators. Lancet Respir
Med. 2020 Nov;8(11):1121-1131. doi: 10.1016/S2213-2600(20)30328-3.
Epub 2020 Aug 13. PMID: 32798468
- SARS-CoV-2 Does Not Spread
Through Extracorporeal Membrane Oxygenation or Dialysis
Membranes. Dres M, Burrel S, Boutolleau D, Voiriot G,
Demoule A, Combes A, Lebreton G, Schmidt M. Am J Respir Crit Care
Med. 2020 Aug 1;202(3):458-460. doi: 10.1164/rccm.202004-1339LE.
PMID: 32525400
- Extracorporeal membrane
oxygenation in children with COVID-19: Preliminary report from
the collaborative EuroELSO prospective survey. Di Nardo M,
Hoskote A, Thiruchelvam T, Lillie J, Horan M, Belda Hofheinz S,
Dupic L, Gimeno R, De Piero ME, Lo Coco V, Roeleveld P, Davidson M,
Jones T, Broman LM, Lorusso R, Belohlavek J; EuroELSO Neonatal &
Pediatric Working Group & collaborators on COVID-19. ASAIO J. 2020
Oct 1. doi: 10.1097/MAT.0000000000001309. Online ahead of print.
PMID: 33009172
- Ventilator-associated pneumonia
in patients with SARS-CoV-2-associated acute respiratory
distress syndrome requiring ECMO: a retrospective cohort
study. Luyt CE, Sahnoun T, Gautier M, Vidal P, Burrel S,
Pineton de Chambrun M, Chommeloux J, Desnos C, Arzoine J,
Nieszkowska A, Bréchot N, Schmidt M, Hekimian G, Boutolleau D,
Robert J, Combes A, Chastre J. Ann Intensive Care. 2020 Nov
23;10(1):158. doi: 10.1186/s13613-020-00775-4. PMID: 33230710
- Extracorporeal Membrane
Oxygenation for Patients With COVID-19 in Severe Respiratory
Failure. Mustafa AK, Alexander PJ, Joshi DJ, Tabachnick DR,
Cross CA, Pappas PS, Tatooles AJ. JAMA Surg. 2020 Aug
11;155(10):990-2. doi: 10.1001/jamasurg.2020.3950. Online ahead of
print. PMID: 32780089
- Successful Treatment of Pregnant
and Postpartum Women with Severe COVID-19 Associated Acute
Respiratory Distress Syndrome with Extracorporeal Membrane
Oxygenation. Barrantes JH, Ortoleva J, O'Neil ER, Suarez EE,
Larson SB, Rali AS, Agerstrand C, Grazioli L, Chatterjee S, Anders
M. ASAIO J. 2020 Nov 20. doi: 10.1097/MAT.0000000000001357. Online
ahead of print. PMID: 33229971
- Viewpoints
- Planning and provision of ECMO
services for severe ARDS during the COVID-19 pandemic and other
outbreaks of emerging infectious diseases. Ramanathan K,
Antognini D, Combes A, Paden M, Zakhary B, Ogino M, MacLaren G, Brodie
D, Shekar K. Lancet Respir Med. 2020 May;8(5):518-526. doi:
10.1016/S2213-2600(20)30121-1. Epub 2020 Mar 20. PMID: 32203711
- Preparing for the Most Critically
Ill Patients With COVID-19: The Potential Role of Extracorporeal
Membrane Oxygenation. MacLaren G, Fisher D, Brodie D. JAMA. 2020
Apr 7;323(13):1245-1246. doi: 10.1001/jama.2020.2342. PMID: 32074258
- Provision of ECPR during COVID-19:
evidence, equity, and ethical dilemmas. Worku E, Gill D, Brodie
D, Lorusso R, Combes A, Shekar K. Crit Care. 2020 Jul 27;24(1):462. doi:
10.1186/s13054-020-03172-2.PMID: 32718340
- What's new in ECMO for COVID-19?
MacLaren G, Combes A, Brodie D. Intensive Care Med. 2020 Nov 12:1-3.
doi: 10.1007/s00134-020-06284-z. Online ahead of print. PMID: 33180168
- ECMO during the COVID-19 pandemic:
when is it unjustified? Abrams D, Lorusso R, Vincent JL, Brodie
D. Crit Care. 2020 Aug 17;24(1):507. doi: 10.1186/s13054-020-03230-9.
PMID 32807189
- ECMO for severe ARDS associated with
COVID-19: now we know we can, but should we? Shekar K, Slutsky
AS, Brodie D. Lancet Respir Med. 2020 Nov;8(11):1066-1068. doi:
10.1016/S2213-2600(20)30357-X. Epub 2020 Aug 13. PMID: 32798470
- COVID-19 and ECMO: the interplay
between coagulation and inflammation-a narrative review.
Kowalewski M, Fina D, Słomka A, Raffa GM, Martucci G, Lo Coco V, De
Piero ME, Ranucci M, Suwalski P, Lorusso R. Crit Care. 2020 May
8;24(1):205. doi: 10.1186/s13054-020-02925-3.PMID: 32384917
- COVID-19-associated acute
respiratory distress syndrome: is a different approach to
management warranted? Fan E, Beitler JR, Brochard L,
Calfee CS, Ferguson ND, Slutsky AS, Brodie D. Lancet Respir Med. 2020
Aug;8(8):816-821. doi: 10.1016/S2213-2600(20)30304-0. Epub 2020 Jul
6.PMID: 32645311
- Extracorporeal life support for
adults with acute respiratory distress syndrome. Combes
A, Schmidt M, Hodgson CL, Fan E, Ferguson ND, Fraser JF, Jaber S,
Pesenti A, Ranieri M, Rowan K, Shekar K, Slutsky AS, Brodie D. Intensive
Care Med. 2020 Dec;46(12):2464-2476. doi: 10.1007/s00134-020-06290-1.
Epub 2020 Nov 2.PMID: 33140180
FDA Approves ECMO Use for Equipment During Pandemic
FDA released guidance for industry and FDA staff on Enforcement Policy for Extracorporeal Membrane Oxygenation and Cardiopulmonary Bypass Devices During the Coronavirus Disease 2019 (COVID-19) Public Health Emergency.
https://www.fda.gov/media/136734/download
Special Discussion
Messages from ELSO’s President
on COVID-19
An Update on ECMO in COVID19 from ELSO’s President, Dr. Mark
Ogino.
Posted May 4, 2020.
ELSO's response to COVID-19 from ELSO's President, Dr. Mark Ogino. The use of
ECMO in treating COVID-19 patients.
Posted March 14, 2020.
Webinars & Podcasts
Webinar:
Critical care & ECMO in the era of COVID-19: why data matters
On Jun 08, 2020 ELSO hosted a webinar: 'Critical care & ECMO in the era of
COVID-19: why data matters'. Critical care & ECMO in the era of COVID-19: why
data matters! ELSO webinar, moderated by Dr. Robert Bartlett & Matt Paden,
highlighting the current research underway focused on better understanding the
impact of COVID-19, and the role of extracorporeal support and ICU care in
patients with SARS-CoV-2 Coronavirus infection. Topics & speakers:
ELSO Registry and the live dashboard for COVID-19 Cases: Matt Paden & Ryan
Barbaro
EuroELSO Survey on ECLS in COVID-19, Roberto Lorusso & Jan Bělohlávek
COVID-Critical Care Consortium, John Fraser & Heidi Dalton
On April 22, 2020 ELSO hosted a webinar ‘ECMO COVID-19 What we have learned.’
Speakers & topics: Christian Bermudez - ECMO Center Organization and Regional
Coordination; Holt Murray - Regional ECMO Coordination; 10 years in 10 minutes
Erik Osborn - COVID-19 & ECMO Experiences & Management; Tim Maul - Inflammation
& Coagulation for SARS-CoV-2 a Perfusionist’s Perspective; Troy Seelhammer -
ECMO in COVID-19: Is There a Role for Bivalirudin? All slides available at https://bit.ly/2RZpAHc
Watch the STS Webinar from Thursday, April 23rd - Webinar on COVID Crisis
Cardiothoracic surgeons around the globe quickly adapted to the challenges
presented by the COVID pandemic. Among the issues has been an increased need for
extracorporeal membrane oxygenation (ECMO), without the required resources to
meet the demand.
Explain the role of the Extracorporeal Life Support Organization (ELSO) in
guiding physicians and other practitioners through preparations for the COVID
pandemic.
On Friday, April 3rd, 2020 at 4:00pm Eastern ELSO hosted a webinar: The Power of
Connection. In that webinar, we discussed the power of sharing information in
real-time using WhatsApp COVID19 chat rooms so that we can share what we are
learning about COVID-19 patients on ECMO quickly (Tammy Friedrich, Holli
Williams, Amy Hackman). We also shared the experiences with COVID-19 patients on
ECMO in Seattle (Jenelle Badulak), NYC (Cara Agerstrand), and Paris (Matthieu
Schmidt). You can view the webinar anytime above.
Preparing to support #COVID19 patients on #ECMO: first ELSO
webinar dedicated to the role of extracorporeal support in patients
with #SARSCoV2 infection, speakers:
Dr. Ram Ramanathan
Dr. Kiran Shekar
Dr. Michael Matthay