ECLS | Extracorporeal Membrane Oxygenation

Registry Dashboard of ECMO-Supported COVID-19 Patient Data

Thank you for helping ELSO disseminate information by entering your experience in the ELSO Registry as soon as ECMO is implanted - before the run is complete. Instructions for entering data in the Registry and COVID-19 addendum can be found on the Data Definitions page.

We recognize you cannot complete and submit the entire ELSO Registry case report form prior to completion of the ECMO run and discharge from the hospital, but we would still like to have the data you know now.

To address concerns about incomplete data we report three nested data sets to accommodate the fact that different patients will be at different stages of care (and thus have more or less incomplete data). Also when considering the data please understand that the data displayed is a real-time data stream and subject to change as more patient information is accrued and as centers update the ELSO Registry Case Report Form and the ELSO COVID-19 addendum.



COVID-19 Cases on ECMO in the ELSO Registry

Total COVID-19 Cases COVID-19
Confirmed Cases
14,620
Total counts of COVID-19 confirmed patients.

COVID-19 ECMO counts by ELSO Chapter

Still on ECMO Still Hospitalized at ELSO Center Total (n)
All ELSO 572 892 14,678
          North America 220 341 9,537
          Europe 177 260 2,995
          Asia Pacific 29 37 250
          Latin America 103 175 940
          SWAAC 43 79 956
Reports counts of ECMO-supported suspected or confirmed COVID-19 cases by ELSO Chapter

Filters affect the data shown in the tables below:

Year To Date

Region

Patient Age


Patients who initiated ECMO at
least 90 days ago
COVID-19
Confirmed
13,475
COVID-19
In-hospital Mortality
47%

Outcomes

Pre-ECMO Patient Factors

Patient-level summaries of COVID ECMO runs. All categorical variables are given as 'percentage (count)'
Total ARDS Cohort
Number cases 13475 10170
Age(years)
Median(IQR) 47(37,56) 47(38,56)
# observed 13475 10170
BMI, kg/m2
Median(IQR) 32(28,38) 32(28,38)
# observed 12623 9518
Sex
Male 69%(9246) 70%(7094)
Female 31%(4226) 30%(3074)
# observed 13472 10168
Race/Ethnicity
Black 11%(1479) 10%(1061)
White (Non-Hispanic) 44%(5896) 44%(4426)
Asian 8%(1102) 8%(777)
Mid East, N African 4%(599) 5%(516)
Other 3%(410) 3%(308)
Unknown 4%(603) 5%(466)
Multiple 5%(619) 5%(527)
Hispanic 21%(2767) 21%(2089)
# observed 13475 10170
Pre-ECMO Comorbidities
No comorbidity 25%(3365) 24%(2402)
Cancer 2%(219) 2%(166)
Pregnancy 4%(564) 4%(418)
Immunocompromised 4%(544) 4%(409)
Diabetes 24%(3266) 25%(2555)
Pre-existing heart disease 4%(492) 3%(278)
Pre-existing lung disease 4%(483) 4%(374)
Pre-existing renal insuff. 3%(364) 3%(269)
Frailty 1%(93) 1%(57)
Asthma 11%(1424) 11%(1096)
BMI $> 30 \mathrm{kg}/\mathrm{m}^2$ 51%(6816) 53%(5361)
Hypertension 31%(4223) 33%(3326)
# observed 13475 10170
Acute illness
ARDS 80%(10725) 100%(10170)
Acute heart failure 7%(999) 5%(492)
Myocarditis 2%(278) 1%(58)
Acute kidney injury 25%(3396) 26%(2662)
# observed 13475 10170
Pre-ECMO Cardiac Arrest
Yes 6%(743) 3%(293)
No 94%(12593) 97%(9767)
# observed 13336 10060
Pre-ECMO Co-Infection
No Co-infection 49%(6629) 47%(4739)
Bacterial pneumonia 44%(5954) 47%(4789)
Co-viral infection 9%(1265) 9%(916)
Blood stream infection 17%(2288) 19%(1883)
Urinary tract infection 7%(1009) 8%(842)
# observed 13473 10168

Pre-ECMO Interventions

Support and therapies. All categorical variables are given as 'percentage (count)'
PreECLS PreECLS
Number cases 13475 10170
Noninvasive ventilation
Noninvasive ventilation prior to intubation 77%(10413) 80%(8169)
BiPAP 39%(5216) 41%(4176)
CPAP 13%(1818) 12%(1270)
HFNC 51%(6936) 55%(5617)
# observed 13473 10168
Pre-ECLS intubation (days)
Median(IQR) 2.9(0.8,6.0) 3.2(1.0,6.1)
# observed 11547 8754
Ventilator mode
Conventional 96%(11348) 97%(8799)
# observed 11804 9073
PEEP, cm H2O
Median(IQR) 14.0(10.0,16.0) 14.0(10.0,16.0)
# observed 10579 8242
PIP, cm H2O
Median(IQR) 33.0(30.0,38.0) 34.0(30.0,38.0)
# observed 8596 6626
FiO2
Median(IQR) 1.00(0.95,1.00) 1.00(1.00,1.00)
# observed 10514 8076
PaO2/FiO2
Median(IQR) 70(57,90) 70(57,88)
# observed 10287 7908
PCO2
Median(IQR) 60(50,75) 61(51,75)
# observed 10878 8326
Pre-ECMO Support
Prone positioning 54%(7195) 57%(5805)
# observed 13408 10119
Neuromuscular blockers 70%(9331) 73%(7402)
# observed 13407 10116
Inhaled pulmonary vasodilators 29%(3925) 32%(3227)
# observed 13408 10119
Any vasoactive support 57%(7654) 56%(5678)
# observed 13401 10114
Norepinephrine 51%(6806) 51%(5160)
# observed 13401 10114
Therapies, Immunomodulators
Any therapy 88%(11899) 91%(9280)
Glucocorticoids 79%(10621) 82%(8323)
IVIG 2%(328) 2%(176)
Anti-cytokine 23%(3075) 25%(2518)
Lopinavir/Ritonavir 2%(262) 2%(219)
JAK inhibition 3%(441) 4%(375)
Chloroquine/hydroxychloroquine 8%(1011) 8%(815)
Remdesivir 49%(6595) 52%(5269)
# observed 13475 10170
Support type
Respiratory 94%(12688) 100%(10150)
Cardiac 4%(604) 0%(8)
ECPR 1%(183) 0%(12)
# observed 13475 10170

Patient Status & Complications

Outcomes
Total ARDS Cohort
Last known patient status
Discharged alive to home or acute rehabilitation 26%(3500) 25%(2580)
Discharged alive to long-term acute care or unspecified location 12%(1584) 13%(1298)
Discharged to another hospital 12%(1628) 11%(1141)
Remain in the hospital (discharged from ICU) 0%(8) 0%(4)
Remain in the ICU 1%(185) 1%(139)
In-hospital death 49%(6570) 49%(5008)
Tracheostomy 47%(5707) 50%(4656)
# observed 12266 9293
Select complications
Seizures 1%(103) 1%(77)
# observed 13341 10059
CNS infarction by US/CT/MRI 2%(212) 1%(135)
# observed 13341 10059
CNS hemorrhage by US/CT/MRI 7%(873) 7%(693)
# observed 13341 10059
Hemolysis 8%(1009) 8%(789)
# observed 13341 10059
Oxygenator failure 21%(2838) 23%(2341)
# observed 13341 10059
Pump failure 2%(305) 2%(245)
# observed 13341 10059
Circuit change 12%(1597) 13%(1274)
# observed 13341 10059
Thrombosis/Clots in circuit component 3%(452) 4%(361)
# observed 13341 10059
Discharge location
Home 30%(2015) 30%(1492)
Transfer to LTAC or Rehab
Transfer to another hospital 24%(1628) 23%(1141)
Other/Unknown 5%(338) 5%(233)
*N/A - Data elements with n<5 are not displayed.

ELSO Ownership, No Rights to Publication, Disclaimer

The Dashboard content has been compiled and reported from a variety of sources, is not independently verified by ELSO, and is subject to change without notice. ELSO and its authorized agents and contractors make no representations or warranties about the quality, content, completeness, suitability, adequacy, sequence, accuracy, or timeliness of such content. ELSO disclaims any responsibility for any inaccuracy, whether by inclusion or omission, on the Dashboard or the Site, and disclaims any responsibility for subsequent change or withdrawal of data shown on the Dashboard or the Site, which is subject to alteration without notice. ELSO disclaims any and all warranties regarding this information and all liability whatsoever relating thereto. Any person who uses information obtained from this Dashboard does so at his or her own risk.

The Dashboard is provided as a public service to facilitate real-time sharing of information during the COVID-19 crisis for educational purposes only by health practitioners. ELSO owns the compilation of all data, and its use or publication by any third party is strictly forbidden. Publication or representation of this information as if it were statistically significant or part of a scientific study is irresponsible and misleading.

The tables are consistent with the Lancet Publication article but the data presented here is real time

Barbaro RP, MacLaren G, Boonstra PS, Iwashyna TJ, Slutsky AS, Fan E, Bartlett RH, Tonna JE, Hyslop R, Fanning JJ, Rycus PT, Hyer SJ, Anders MM, Agerstrand CL, Hryniewicz K, Diaz R, Lorusso R, Combes A, Brodie D, the Extracorporeal Life Support Organization. Extracorporeal Membrane Oxygenation Support in COVID-19: The Registry Report from the Extracorporeal Life Support Organization. Lancet. 2020; [In Press].

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